Table 1 Penetrance of phenotypes in Ptdsr -/- mice from E9.5 to E18.5, as detected by gross morphology
Dysmorphic phenotypes | Ratio in analyzed mice (affected/total) | Penetrance (%) |
|---|---|---|
Head malformations | 9/198 | 4.5 |
cleft | 4/198 | 2.0 |
others | 5/198 | 2.5 |
Edema (E12.5-E15.5) | 15/155 | 9.7 |
Pale appearance (= E14.5) | 72/72 | 100 |
Ocular lesions | 28/198 | 14.1 |
unilaterally absent eyes | 21/198 | 10.6 |
right | 16/198 | 8.1 |
left | 5/198 | 2.5 |
bilaterally absent eyes | 7/198 | 3.5 |