TY - JOUR AU - Nusslein-Volhard, C. AU - Wieschaus, E. PY - 1980 DA - 1980// TI - Mutations affecting segment number and polarity in Drosophila. JO - Nature VL - 287 UR - https://doi.org/10.1038/287795a0 DO - 10.1038/287795a0 ID - Nusslein-Volhard1980 ER - TY - JOUR AU - Ingham, P. W. AU - McMahon, A. P. PY - 2001 DA - 2001// TI - Hedgehog signaling in animal development: paradigms and principles. JO - Genes Dev VL - 15 UR - https://doi.org/10.1101/gad.938601 DO - 10.1101/gad.938601 ID - Ingham2001 ER - TY - JOUR AU - Xie, J. AU - Murone, M. AU - Luoh, S. M. AU - Ryan, A. AU - Gu, Q. AU - Zhang, C. AU - Bonifas, J. M. AU - Lam, C. W. AU - Hynes, M. AU - Goddard, A. PY - 1998 DA - 1998// TI - Activating Smoothened mutations in sporadic basal-cell carcinoma. JO - Nature VL - 391 UR - https://doi.org/10.1038/34201 DO - 10.1038/34201 ID - Xie1998 ER - TY - JOUR AU - Stone, D. M. AU - Hynes, M. AU - Armanini, M. AU - Swanson, T. A. AU - Gu, Q. AU - Johnson, R. L. AU - Scott, M. P. AU - Pennica, D. AU - Goddard, A. AU - Phillips, H. PY - 1996 DA - 1996// TI - The tumour-suppressor gene patchedencodes a candidate receptor for Sonic hedgehog. JO - Nature VL - 384 UR - https://doi.org/10.1038/384129a0 DO - 10.1038/384129a0 ID - Stone1996 ER - TY - JOUR AU - Denef, N. AU - Neubuser, D. AU - Perez, L. AU - Cohen, S. M. PY - 2000 DA - 2000// TI - Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. JO - Cell VL - 102 UR - https://doi.org/10.1016/S0092-8674(00)00056-8 DO - 10.1016/S0092-8674(00)00056-8 ID - Denef2000 ER - TY - JOUR AU - Cuenda, A. AU - Alessi, D. R. PY - 2000 DA - 2000// TI - Use of kinase inhibitors to dissect signaling pathways. JO - Methods Mol Biol VL - 99 ID - Cuenda2000 ER - TY - JOUR AU - Sebolt-Leopold, J. S. PY - 2000 DA - 2000// TI - Development of anticancer drugs targeting the MAP kinase pathway. JO - Oncogene VL - 19 UR - https://doi.org/10.1038/sj.onc.1204083 DO - 10.1038/sj.onc.1204083 ID - Sebolt-Leopold2000 ER - TY - JOUR AU - Lee, J. C. AU - Kassis, S. AU - Kumar, S. AU - Badger, A. AU - Adams, J. L. PY - 1999 DA - 1999// TI - p38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials. JO - Pharmacol Ther VL - 82 UR - https://doi.org/10.1016/S0163-7258(99)00008-X DO - 10.1016/S0163-7258(99)00008-X ID - Lee1999 ER - TY - JOUR AU - Cooper, M. K. AU - Porter, J. A. AU - Young, K. E. AU - Beachy, P. A. PY - 1998 DA - 1998// TI - Teratogen-mediated inhibition of target tissue response to Shh signaling. JO - Science VL - 280 UR - https://doi.org/10.1126/science.280.5369.1603 DO - 10.1126/science.280.5369.1603 ID - Cooper1998 ER - TY - JOUR AU - Incardona, J. P. AU - Gaffield, W. AU - Kapur, R. P. AU - Roelink, H. PY - 1998 DA - 1998// TI - The teratogenic Veratrumalkaloid cyclopamine inhibits sonic hedgehog signal transduction. JO - Development VL - 125 ID - Incardona1998 ER - TY - JOUR AU - Taipale, J. AU - Chen, J. K. AU - Cooper, M. K. AU - Wang, B. AU - Mann, R. K. AU - Milenkovic, L. AU - Scott, M. P. AU - Beachy, P. A. PY - 2000 DA - 2000// TI - Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. JO - Nature VL - 406 UR - https://doi.org/10.1038/35023008 DO - 10.1038/35023008 ID - Taipale2000 ER - TY - JOUR AU - Tekki-Kessaris, N. AU - Woodruff, R. AU - Hall, A. C. AU - Gaffield, W. AU - Kimura, S. AU - Stiles, C. D. AU - Rowitch, D. H. AU - Richardson, W. D. PY - 2001 DA - 2001// TI - Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. JO - Development VL - 128 ID - Tekki-Kessaris2001 ER - TY - JOUR AU - van den Brink, G. R. AU - Hardwick, J. C. AU - Tytgat, G. N. AU - Brink, M. A. AU - Ten Kate, F. J. AU - Van Deventer, S. J. AU - Peppelenbosch, M. P. PY - 2001 DA - 2001// TI - Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. JO - Gastroenterology VL - 121 UR - https://doi.org/10.1053/gast.2001.26261 DO - 10.1053/gast.2001.26261 ID - van den Brink2001 ER - TY - JOUR AU - Kim, S. K. AU - Melton, D. A. PY - 1998 DA - 1998// TI - Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. JO - Proc Natl Acad Sci USA VL - 95 UR - https://doi.org/10.1073/pnas.95.22.13036 DO - 10.1073/pnas.95.22.13036 ID - Kim1998 ER - TY - JOUR AU - Chiang, C. AU - Swan, R. Z. AU - Grachtchouk, M. AU - Bolinger, M. AU - Litingtung, Y. AU - Robertson, E. K. AU - Cooper, M. K. AU - Gaffield, W. AU - Westphal, H. AU - Beachy, P. A. AU - Dlugosz, A. A. PY - 1999 DA - 1999// TI - Essential role for Sonic hedgehog during hair follicle morphogenesis. JO - Dev Biol VL - 205 UR - https://doi.org/10.1006/dbio.1998.9103 DO - 10.1006/dbio.1998.9103 ID - Chiang1999 ER - TY - JOUR AU - Sukegawa, A. AU - Narita, T. AU - Kameda, T. AU - Saitoh, K. AU - Nohno, T. AU - Iba, H. AU - Yasugi, S. AU - Fukuda, K. PY - 2000 DA - 2000// TI - The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. JO - Development VL - 127 ID - Sukegawa2000 ER - TY - STD TI - Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Gatchalian C, Porter JA, Rubin LL, Wang FY: Identification of novel inhibitors of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci USA. ID - ref17 ER - TY - JOUR AU - Tian, S. S. AU - Lamb, P. AU - King, A. G. AU - Miller, S. G. AU - Kessler, L. AU - Luengo, J. I. AU - Averill, L. AU - Johnson, R. K. AU - Gleason, J. G. AU - Pelus, L. M. PY - 1998 DA - 1998// TI - A small, nonpeptidyl mimic of granulocyte colony-stimulating factor. JO - Science VL - 281 UR - https://doi.org/10.1126/science.281.5374.257 DO - 10.1126/science.281.5374.257 ID - Tian1998 ER - TY - JOUR AU - Zhang, B. AU - Salituro, G. AU - Szalkowski, D. AU - Li, Z. AU - Zhang, Y. AU - Royo, I. AU - Vilella, D. AU - Diez, M. T. AU - Pelaez, F. AU - Ruby, C. PY - 1999 DA - 1999// TI - Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. JO - Science VL - 284 UR - https://doi.org/10.1126/science.284.5416.974 DO - 10.1126/science.284.5416.974 ID - Zhang1999 ER - TY - JOUR AU - Sasaki, H. AU - Hui, C. AU - Nakafuku, M. AU - Kondoh, H. PY - 1997 DA - 1997// TI - A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. JO - Development VL - 124 ID - Sasaki1997 ER - TY - JOUR AU - Taylor, F. R. AU - Wen, D. AU - Garber, E. A. AU - Carmillo, A. N. AU - Baker, D. P. AU - Arduini, R. M. AU - Williams, K. P. AU - Weinreb, P. H. AU - Rayhorn, P. AU - Hronowski, X. PY - 2001 DA - 2001// TI - Enhanced potency of human Sonic hedgehog by hydrophobic modification. JO - Biochemistry VL - 40 UR - https://doi.org/10.1021/bi002487u DO - 10.1021/bi002487u ID - Taylor2001 ER - TY - JOUR AU - Ericson, J. AU - Rashbass, P. AU - Schedl, A. AU - Brenner-Morton, S. AU - Kawakami, A. AU - van Heyningen, V. AU - Jessell, T. M. AU - Briscoe, J. PY - 1997 DA - 1997// TI - Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. JO - Cell VL - 90 UR - https://doi.org/10.1016/S0092-8674(00)80323-2 DO - 10.1016/S0092-8674(00)80323-2 ID - Ericson1997 ER - TY - JOUR AU - Ericson, J. AU - Morton, S. AU - Kawakami, A. AU - Roelink, H. AU - Jessell, T. M. PY - 1996 DA - 1996// TI - Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. JO - Cell VL - 87 UR - https://doi.org/10.1016/S0092-8674(00)81386-0 DO - 10.1016/S0092-8674(00)81386-0 ID - Ericson1996 ER - TY - JOUR AU - Tanabe, Y. AU - William, C. AU - Jessell, T. M. PY - 1998 DA - 1998// TI - Specification of motor neuron identity by the MNR2 homeodomain protein. JO - Cell VL - 95 UR - https://doi.org/10.1016/S0092-8674(00)81783-3 DO - 10.1016/S0092-8674(00)81783-3 ID - Tanabe1998 ER - TY - JOUR AU - Goodrich, L. V. AU - Milenkovic, L. AU - Higgins, K. M. AU - Scott, M. P. PY - 1997 DA - 1997// TI - Altered neural cell fates and medulloblastoma in mouse patched mutants. JO - Science VL - 277 UR - https://doi.org/10.1126/science.277.5329.1109 DO - 10.1126/science.277.5329.1109 ID - Goodrich1997 ER - TY - JOUR AU - Zhang, X. M. AU - Ramalho-Santos, M. AU - McMahon, A. P. PY - 2001 DA - 2001// TI - Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. JO - Cell VL - 105 UR - https://doi.org/10.1016/S0092-8674(01)00385-3 DO - 10.1016/S0092-8674(01)00385-3 ID - Zhang2001 ER - TY - JOUR AU - Chiang, C. AU - Litingtung, Y. AU - Lee, E. AU - Young, K. E. AU - Corden, J. L. AU - Westphal, H. AU - Beachy, P. A. PY - 1996 DA - 1996// TI - Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. JO - Nature VL - 383 UR - https://doi.org/10.1038/383407a0 DO - 10.1038/383407a0 ID - Chiang1996 ER - TY - BOOK PY - 2000 DA - 2000// TI - Current Protocols in Pharmacology PB - John Wiley and Sons CY - New York ID - ref28 ER - TY - JOUR AU - Samama, P. AU - Cotecchia, S. AU - Costa, T. AU - Lefkowitz, R. J. PY - 1993 DA - 1993// TI - A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. JO - J Biol Chem VL - 268 ID - Samama1993 ER - TY - JOUR AU - Taipale, J. AU - Beachy, P. A. PY - 2001 DA - 2001// TI - The Hedgehog and Wnt signalling pathways in cancer. JO - Nature VL - 411 UR - https://doi.org/10.1038/35077219 DO - 10.1038/35077219 ID - Taipale2001 ER - TY - JOUR AU - De Lean, A. AU - Stadel, J. M. AU - Lefkowitz, R. J. PY - 1980 DA - 1980// TI - A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. JO - J Biol Chem VL - 255 ID - De Lean1980 ER - TY - JOUR AU - Howard, A. D. AU - McAllister, G. AU - Feighner, S. D. AU - Liu, Q. AU - Nargund, R. P. AU - Van der Ploeg, L. H. AU - Patchett, A. A. PY - 2001 DA - 2001// TI - Orphan G-protein-coupled receptors and natural ligand discovery. JO - Trends Pharmacol Sci VL - 22 UR - https://doi.org/10.1016/S0165-6147(00)01636-9 DO - 10.1016/S0165-6147(00)01636-9 ID - Howard2001 ER - TY - JOUR AU - Civelli, O. AU - Nothacker, H. P. AU - Saito, Y. AU - Wang, Z. AU - Lin, S. H. AU - Reinscheid, R. K. PY - 2001 DA - 2001// TI - Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors. JO - Trends Neurosci VL - 24 UR - https://doi.org/10.1016/S0166-2236(00)01763-X DO - 10.1016/S0166-2236(00)01763-X ID - Civelli2001 ER - TY - JOUR AU - Dohlman, H. G. AU - Thorner, J. AU - Caron, M. G. AU - Lefkowitz, R. PY - 1991 DA - 1991// TI - Model systems for the study of seven-transmembrane-segment receptors. JO - Annu Rev Biochem VL - 60 UR - https://doi.org/10.1146/annurev.bi.60.070191.003253 DO - 10.1146/annurev.bi.60.070191.003253 ID - Dohlman1991 ER - TY - JOUR AU - Christopoulos, A. PY - 2002 DA - 2002// TI - Allosteric binding sites on cell-surface receptors: novel targets for drug discovery. JO - Nat Rev Drug Discov VL - 1 UR - https://doi.org/10.1038/nrd746 DO - 10.1038/nrd746 ID - Christopoulos2002 ER - TY - JOUR AU - Taipale, J. AU - Cooper, M. K. AU - Maiti, T. AU - Beachy, P. A. PY - 2002 DA - 2002// TI - Patched acts catalytically to suppress the activity of Smoothened. JO - Nature VL - 418 UR - https://doi.org/10.1038/nature00989 DO - 10.1038/nature00989 ID - Taipale2002 ER - TY - JOUR AU - Bourne, H. R. PY - 1997 DA - 1997// TI - How receptors talk to trimeric G proteins. JO - Curr Opin Cell Biol VL - 9 UR - https://doi.org/10.1016/S0955-0674(97)80054-3 DO - 10.1016/S0955-0674(97)80054-3 ID - Bourne1997 ER - TY - JOUR AU - DeCamp, D. AU - Thompson, T. M. AU - de Sauvage, F. J. AU - Lerner, M. R. PY - 2000 DA - 2000// TI - Smoothened activates Galphai-mediated signaling in frog melanophores. JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.M004055200 DO - 10.1074/jbc.M004055200 ID - DeCamp2000 ER - TY - JOUR AU - Trousse, F. AU - Marti, E. AU - Gruss, P. AU - Torres, M. AU - Bovolenta, P. PY - 2001 DA - 2001// TI - Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog. JO - Development VL - 128 ID - Trousse2001 ER - TY - JOUR AU - Carstea, E. D. AU - Morris, J. A. AU - Coleman, K. G. AU - Loftus, S. K. AU - Zhang, D. AU - Cummings, C. AU - Gu, J. AU - Rosenfeld, M. A. AU - Pavan, W. J. AU - Krizman, D. B. PY - 1997 DA - 1997// TI - Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. JO - Science VL - 277 UR - https://doi.org/10.1126/science.277.5323.228 DO - 10.1126/science.277.5323.228 ID - Carstea1997 ER - TY - JOUR AU - Hampton, R. Y. PY - 2000 DA - 2000// TI - Cholesterol homeostasis: ESCAPe from the ER. JO - Curr Biol VL - 10 UR - https://doi.org/10.1016/S0960-9822(00)00434-6 DO - 10.1016/S0960-9822(00)00434-6 ID - Hampton2000 ER - TY - JOUR AU - Davies, J. P. AU - Chen, F. W. AU - Ioannou, Y. A. PY - 2000 DA - 2000// TI - Transmembrane molecular pump activity of Niemann-Pick C1 protein. JO - Science VL - 290 UR - https://doi.org/10.1126/science.290.5500.2295 DO - 10.1126/science.290.5500.2295 ID - Davies2000 ER - TY - JOUR AU - Traiffort, E. AU - Charytoniuk, D. A. AU - Faure, H. AU - Ruat, M. PY - 1998 DA - 1998// TI - Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain. JO - J Neurochem VL - 70 UR - https://doi.org/10.1046/j.1471-4159.1998.70031327.x DO - 10.1046/j.1471-4159.1998.70031327.x ID - Traiffort1998 ER - TY - JOUR AU - Parmantier, E. AU - Lynn, B. AU - Lawson, D. AU - Turmaine, M. AU - Namini, S. S. AU - Chakrabarti, L. AU - McMahon, A. P. AU - Jessen, K. R. AU - Mirsky, R. PY - 1999 DA - 1999// TI - Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. JO - Neuron VL - 23 UR - https://doi.org/10.1016/S0896-6273(01)80030-1 DO - 10.1016/S0896-6273(01)80030-1 ID - Parmantier1999 ER - TY - JOUR AU - St-Jacques, B. AU - Dassule, H. R. AU - Karavanova, I. AU - Botchkarev, V. A. AU - Li, J. AU - Danielian, P. S. AU - McMahon, J. A. AU - Lewis, P. M. AU - Paus, R. AU - McMahon, A. P. PY - 1998 DA - 1998// TI - Sonic hedgehog signaling is essential for hair development. JO - Curr Biol VL - 8 UR - https://doi.org/10.1016/S0960-9822(98)70443-9 DO - 10.1016/S0960-9822(98)70443-9 ID - St-Jacques1998 ER - TY - JOUR AU - Sato, N. AU - Leopold, P. L. AU - Crystal, R. G. PY - 1999 DA - 1999// TI - Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. JO - J Clin Invest VL - 104 UR - https://doi.org/10.1172/JCI7691 DO - 10.1172/JCI7691 ID - Sato1999 ER - TY - JOUR AU - Pola, R. AU - Ling, L. E. AU - Silver, M. AU - Corbley, M. J. AU - Kearney, M. AU - Pepinsky, R. B. AU - Shapiro, R. AU - Taylor, F. R. AU - Baker, D. P. AU - Asahara, T. AU - Isner, J. M. PY - 2001 DA - 2001// TI - The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. JO - Nat Med VL - 7 UR - https://doi.org/10.1038/89083 DO - 10.1038/89083 ID - Pola2001 ER - TY - JOUR AU - Vortkamp, A. AU - Pathi, S. AU - Peretti, G. M. AU - Caruso, E. M. AU - Zaleske, D. J. AU - Tabin, C. J. PY - 1998 DA - 1998// TI - Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. JO - Mech Dev VL - 71 UR - https://doi.org/10.1016/S0925-4773(97)00203-7 DO - 10.1016/S0925-4773(97)00203-7 ID - Vortkamp1998 ER - TY - JOUR AU - Pepinsky, R. B. AU - Shapiro, R. I. AU - Wang, S. AU - Chakraborty, A. AU - Gill, A. AU - Lepage, D. J. AU - Wen, D. AU - Rayhorn, P. AU - Horan, G. S. AU - Taylor, F. R. PY - 2002 DA - 2002// TI - Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model. JO - J Pharm Sci VL - 91 UR - https://doi.org/10.1002/jps.10052 DO - 10.1002/jps.10052 ID - Pepinsky2002 ER - TY - JOUR AU - Tsuboi, K. AU - Shults, C. W. PY - 2002 DA - 2002// TI - Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's JO - Exp Neurol VL - 173 UR - https://doi.org/10.1006/exnr.2001.7825 DO - 10.1006/exnr.2001.7825 ID - Tsuboi2002 ER - TY - JOUR AU - Chen, J. K. AU - Taipale, J. AU - Cooper, M. AU - Beachy, P. A. PY - 2002 DA - 2002// TI - Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. JO - Genes Dev VL - 16 UR - https://doi.org/10.1101/gad.1025302 DO - 10.1101/gad.1025302 ID - Chen2002 ER - TY - JOUR AU - Chen, J. K. AU - Taipale, J. AU - Young, J. E. AU - Maiti, T. AU - Beachy, P. A. PY - 2002 DA - 2002// TI - Small molecule modulation of Smoothened activity. JO - Proc Natl Acad Sci USA VL - 99 UR - https://doi.org/10.1073/pnas.182542899 DO - 10.1073/pnas.182542899 ID - Chen2002 ER -