Table 1 Examples of diseases caused by loss of or ectopic function of the HH-GLI signaling pathway, and the possible agents that could, in principle, be used as therapeutics
From: The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
Disease type | Potential therapeutic | ||
|---|---|---|---|
Gain-of-function: | Basal cell carcinoma | Antagonist: | Anti-HH antibodies |
| Â | Medulloblastoma | Â | Forskolin |
| Â | Rhabdomyosarcoma | Â | Cyclopamine |
| Â | Â | Â | Cur61414 |
| Â | Â | Â | GLI repressors |
Loss-of-function: | Holoprosencephaly | Agonist: | SHH |
| Â | Â | Â | Hh-Ag* |