Figure 2
From: Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors
Insulin signaling controls cell size and number through changes in rates of cell growth and division. (a) Because cell growth and division rates are closely matched in wild-type cells, cell size is kept at a steady state. (b) By reducing cell growth and division rates in parallel, overexpression of dFOXO causes a reduction in cell number but maintains normal cell size. (c) Mutations in chico/IRS1 result in a reduction in both cell number and size, indicating that the rate of cell growth is decreased to a greater extent than the rate of cell division. (d) In dS6K mutants, cell size is reduced but cell number is normal, suggesting a decrease in the rate of cell growth but not cell division.