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Figure 4 | Journal of Biology

Figure 4

From: The ribosome returned

Figure 4

The translation cycle. The intiation of translation is complete once an aminoacyl tRNA charged with formylated methionine has been placed in the P site bound to the initiating AUG codon of an mRNA. Elongation begins when a second aminoacyl tRNA recognizes its cognate codon and binds in the A site. This is followed by transfer of the amino acid from the tRNA in the P site to form a peptide bond with the amino acid attached to the tRNA in the A site, and translocation of the two tRNAs into the E and the P site, respectively. This sequence is iterated until a stop codon is encountered, the completed protein is released, and the ribosome disassembles, at termination of the translation cycle (not shown).

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