Figure 1

Human protein-protein interaction network. Proteins are shown as yellow nodes. Interactions from CCSB-HI1 (Rual et al., Nature 2005, 437:1173–1178) and from (Stelzl et al., Cell 2005, 122:957–968) are shown as red and green edges, respectively. Literature-Curated Interactions (LCI) extracted from databases (BIND, DIP, HPRD, INTACT and MINT) that are supported by at least 2 publications are shown as blue edges. Interactions common to two of those 3 datasets are represented with the corresponding mixed color (yellow for (Rual et al., 2005) and (Stelzl et al., 2005), magenta for Rual and LCI, cyan for (Stelzl et al., 2005) and LCI). Interactions common to all 3 datasets are shown as black edges. (Figure kindly provided by Nicolas Simonis and Marc Vidal.)