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Table 1 The 27 genes included in the two signatures

From: Distant metastasis: not out of reach any more

Gene symbol

Gene name

Hu et al. [3]

Tutt et al. [4]

Basal*

16-kinases

GGI

ADM

Adrenomedullin

Yes

 

Up

  

ANGPTL4

Angiopoietin-like 4

Yes

    

C14orf58

Chromosome 14 open reading frame 58

Yes

 

Up

  

DDIT4

DNA-damage-inducible transcript 4

Yes

 

Up

  

FABP5

Fatty acid binding protein 5 (psoriasis-associated)

Yes

 

Up

  

GAL

Galanin

Yes

 

Up

  

NDRG1

N-myc downstream regulated gene 1

Yes

 

Up

  

NP

Nucleoside phosphorylase

Yes

 

Up

  

PLOD1

Procollagen-lysine 1,2-oxoglutarate 5-dioxygenase 1

Yes

 

Up

  

RRAGD

Ras-related GTP binding D

Yes

 

Up

  

SLC16A3

Solute carrier family 16 (monocarboxylic acid transporters), member 3

Yes

    

UCHL1

Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Yes

 

Up

  

VEGF

Vascular endothelial growth factor

Yes

 

Up

  

BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)

 

Yes

Up

Yes

Yes

CCNB1

Cyclin B1

 

Yes

Up

 

Yes

CENPA

Centromere protein A, 17 kDa

 

Yes

Up

 

Yes

DC13

DC13 protein

 

Yes

  

Yes

DIAPH3

Diaphanous homolog 3 (Drosophila)

 

Yes

   

MELK

Maternal embryonic leucine zipper kinase

 

Yes

Up

Yes

 

MYBL2

v-Myb myeloblastosis viral oncogene homolog (avian)-like 2

 

Yes

Up

 

Yes

ORC6L

Origin recognition complex, subunit 6 like (yeast)

 

Yes

Up

  

PKMYT1

Protein kinase, membrane associated tyrosine/threonine 1

 

Yes

Up

  

PRR11

Proline rich 11

 

Yes

   

RACGAP1

Rac GTPase activating protein 1

 

Yes

   

RFC4

Replication factor C (activator 1) 4, 37 kDa

 

Yes

Up

  

TK1

Thymidine kinase 1, soluble

 

Yes

   

UBE2S

Ubiquitin-conjugating enzyme E2S

 

Yes

Up

  
  1. *Genes upregulated in basal versus luminal A tumors [5]; 16-kinase signature [8]; genomic grade index [7].