Table 1 Prions of mammals, yeast and the filamentous fungus Podospora anserina
From: Prion variants, species barriers, generation and propagation
Organism | Prion | Protein | Normal function | Prion manifestation |
|---|---|---|---|---|
Mammals | TSEs | PrP | Not known | Transmissible spongiform encephalopathy |
Saccharomyces cerevisiae | [URE3] | Ure2 | Nitrogen catabolite repression | Derepression of nitrogen catabolism enzymes and transporters |
| Â | [PSI+] | Sup35 | Translation termination | Read-through of stop codons |
| Â | [PIN+] | Rnq1 | Not known | Rare seeding of [PSI+], other prions |
| Â | [SWI+] | Swi1 | Chromatin remodeling | Poor growth on glycerol, raffinose, galactose |
| Â | [MCA] | Mca1 | Metacaspase (suspected function in apoptosis) | Unknown |
| Â | [OCT+] | Cyc8 | Repression of CYC7 and other genes | Derepression of transcription |
| Â | [MOT3+] | Mot3 | Transcription factor | Cell-wall changes |
Podospora anserina | [Het-s] | HET-s | Heterokaryon incompatibility; meiotic drive (as a prion) | Heterokaryon incompatibility; meiotic drive (as a prion) |