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Table 1 Prions of mammals, yeast and the filamentous fungus Podospora anserina

From: Prion variants, species barriers, generation and propagation

Organism Prion Protein Normal function Prion manifestation
Mammals TSEs PrP Not known Transmissible spongiform encephalopathy
Saccharomyces cerevisiae [URE3] Ure2 Nitrogen catabolite repression Derepression of nitrogen catabolism enzymes and transporters
  [PSI+] Sup35 Translation termination Read-through of stop codons
  [PIN+] Rnq1 Not known Rare seeding of [PSI+], other prions
  [SWI+] Swi1 Chromatin remodeling Poor growth on glycerol, raffinose, galactose
  [MCA] Mca1 Metacaspase (suspected function in apoptosis) Unknown
  [OCT+] Cyc8 Repression of CYC7 and other genes Derepression of transcription
  [MOT3+] Mot3 Transcription factor Cell-wall changes
Podospora anserina [Het-s] HET-s Heterokaryon incompatibility; meiotic drive (as a prion) Heterokaryon incompatibility; meiotic drive (as a prion)