The functional landscape of mouse gene expression

Journal of Biology

Table 1 Domains associated with genes predicted to function in specific biological processes

Predicted function	Enriched domain	Description of domain	Proportion of genes with this domain	-log₁₀ significance (P)
Chromosome organization or DNA packaging	HMG	HMG (high mobility group) box	13/87	10.5
Pregnancy/embryo implantation	Hormone_1	Somatotropin hormone family	3/14	7.3
Acyl-CoA/fatty acid/peroxisome	FabG	Short-chain alcohol dehydrogenase	3/11	6.8
RNA/ribosome metabolism/processing	RRM	RNA recognition motif	10/149	6.6
Carboxylic acid/amine metabolism	ECH	Enoyl-CoA hydratase/isomerase family	3/62	6.2
Humoral immune response	Sp100	The function of this domain is unknown	2/95	6.1
Vision	Uteroglobin	The function of this domain is unknown	3/56	5.9
RNA-nucleus import/export	COG5136	U1 snRNP-specific protein C	2/13	5.7
Microtubule-based process	Smc	Chromosome-segregation ATPases	4/86	5.2

P values were calculated using the hypergeometric P value [48], which compares against expectation from random draws among the 15,443 XM genes with encoded domains. Domain names and descriptions are from the NCBI 'COG' database [65].