Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

Journal of Biology

Table 1 Axis induction by Dsh constructs

Injected RNA	Total number of injected embryos	Complete secondary axes (%)	Partial secondary axes (%)
Experiment 1
Dsh-GFP	150	46.6	25.3
DsNESm-GFP	194	54.6	30.4
Experiment 2
Dsh-GFP	144	28.5	45.1
DsNLSm-GFP	149	0.7	39.5
DsSNLS-GFP	137	24.0	42.3

Embryos were injected as described in Figure 1e,f. Partial secondary axes are defined by a morphologically visible ectopic neural tube up to the hindbrain level. Complete axes are defined by the presence of the secondary head structures, including eyes and cement glands. The frequency of secondary axes in uninjected embryos was less than 1%. Data pooled from several independent experiments are shown.