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Figure 1 | Journal of Biology

Figure 1

From: Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs

Figure 1

Schematic representation of (a) initiation, (b) pre-translocation, (c) post-translocation, and (d) post-termination complexes, referred to as Init, preT and postT, and postTerm, respectively. A, amino-acyl tRNA site on the ribosome; P, peptidyl-tRNA site; E, exit site; L1, ribosomal protein. The large subunit of the ribosome is shown in yellow and the small subunit in blue. The colored ribbons represent tRNAs and the colored balls represent amino acids in aminoacyl- or peptidyl-tRNA. The purple arrow represents RelE, which cleaves the codon shown at the *. The mauve padlock in (d) illustrates a state of the ribosome in which the mRNA is locked, and cannot move in relation to the small subunit. The figure represents a special case in which the postT ribosome has a stop codon (UAA) in the A site, and is therefore also a pre-termination (preTerm) ribosome. For further details see text and Figure 8.

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Journal of Biology

ISSN: 1475-4924