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Figure 4 | Journal of Biology

Figure 4

From: Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function

Figure 4

Modulation of DC activation in vivo during P. chabaudi infection. (a-c) Splenic CD11c+ DCs were isolated from P. chabaudi infected mice at various times (filled bars) or from uninfected controls (open bars) and analyzed by flow cytometry for the indicated markers. Data are expressed as mean fluorescence intensity relative to uninfected samples ± 1 s.d. (*p ≤ 0.05 uninfected versus P. chabaudi-infected). (d-g) Splenic DCs from uninfected (open bars) or P. chabaudi-infected (filled bars; 12 days post-infection) BALB/c mice were restimulated in vitro with LPS (1 μg/ml) for 18 h before analysis by flow cytometry for (d) MHC class II, (e) CD40, (f) CD80 and (g) CD86. Data are expressed as mean fluorescence intensity relative to uninfected, unstimulated samples ± 1 s.d. (*p ≤ 0.05, #p ≤ 0.005 uninfected versus P. chabaudi-infected for the same treatment).

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