Intersection of LC and HTP datasets. (a) Datasets were rendered with the Osprey visualization system  to show overlap between indicated LC and HTP datasets. n, number of nodes; i, number of interactions. (b) Coverage in the HTP physical interaction dataset (collated from five major HTP studies: Uetz et al. , Ito et al. , Ito et al. , Gavin et al. , Ho et al. ) overlaps strongly with coverage in the LC dataset. Proteins present only in the LC dataset were labeled first, followed by proteins present only in the individual HTP datasets. In all plots, a dot represents interaction between proteins on the x- and y-axes. As the networks are undirected, plots are symmetric about the x = y line. Self interactions were removed. (c) Overlap of individual HTP datasets with the LC dataset. Dot plots show all interactions from each HTP dataset partitioned according to proteins that are present in the LC-PI dataset (inside the boxed region) and those that are not (outside the boxed region). 'Ito' indicates data from Ito et al.  rather than Ito et al. . The protein content is different for each dataset and so ordinates are not superimposable. The number of overlapping interactions between each HTP dataset and the LC dataset is shown in parentheses. Note that only a small fraction of interactions in each boxed region actually overlaps with the LC-PI dataset because of the high false-negative rate in HTP data. (d) The number of LC interactions in HTP datasets.