Topological view of the curated protein-protein network of yeast interactions. Adapted from data in Reguly and Breitkreutz et al. . Links are curated from thousands of literature articles referencing proteins in the Saccharoymyces cerevisiae genome. Links shown in black are interactions also recovered by any of five commonly used datasets derived from high-throughput yeast two-hybrid or mass spectrometric screening techniques. Visualization was performed with the VisANT analysis tool .