TY - JOUR AU - Roux, P. P. AU - Blenis, J. PY - 2004 DA - 2004// TI - ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions JO - Microbiol Mol Biol Rev VL - 68 UR - https://doi.org/10.1128/MMBR.68.2.320-344.2004 DO - 10.1128/MMBR.68.2.320-344.2004 ID - Roux2004 ER - TY - JOUR AU - Petak, I. AU - Houghton, J. A. AU - Kopper, L. PY - 2006 DA - 2006// TI - Molecular targeting of cell death signal transduction pathways in cancer JO - Curr Signal Trans Therapy VL - 1 UR - https://doi.org/10.2174/157436206775269217 DO - 10.2174/157436206775269217 ID - Petak2006 ER - TY - JOUR AU - Vantaggiato, C. AU - Formentini, I. AU - Bondanza, A. AU - Bonini, C. AU - Naldini, L. AU - Brambilla, R. PY - 2006 DA - 2006// TI - ERK1 and ERK2 motogen-activated proteins kinases differentially affect Ras-dependent signal transduction and cell growth JO - J Biol VL - 5 UR - https://doi.org/10.1186/jbiol38 DO - 10.1186/jbiol38 ID - Vantaggiato2006 ER - TY - STD TI - KiNET. [http://www.kinexus.ca/kinet] UR - http://www.kinexus.ca/kinet ID - ref4 ER - TY - JOUR AU - Gonzalez, F. A. AU - Raden, D. L. AU - Davis, R. J. PY - 1991 DA - 1991// TI - Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases JO - J Biol Chem VL - 266 ID - Gonzalez1991 ER - TY - JOUR AU - Veeranna AU - Amin, N. D. AU - Ahn, N. G. AU - Jaffe, H. AU - Winters, C. A. AU - Grant, P. AU - Pant, H. C. PY - 1998 DA - 1998// TI - Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M JO - J Neurosci VL - 18 ID - Veeranna1998 ER - TY - JOUR AU - Tanoue, T. AU - Nishida, E. PY - 2003 DA - 2003// TI - Molecular recognitions in the MAP kinase cascades JO - Cell Signal VL - 15 UR - https://doi.org/10.1016/S0898-6568(02)00112-2 DO - 10.1016/S0898-6568(02)00112-2 ID - Tanoue2003 ER - TY - JOUR AU - Fantz, D. A. AU - Jacobs, D. AU - Glossip, D. AU - Kornfeld, K. PY - 2001 DA - 2001// TI - Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M102512200 DO - 10.1074/jbc.M102512200 ID - Fantz2001 ER - TY - JOUR AU - Adachi, M. AU - Fukuda, M. AU - Nishida, E. PY - 1999 DA - 1999// TI - Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer JO - EMBO J VL - 18 UR - https://doi.org/10.1093/emboj/18.19.5347 DO - 10.1093/emboj/18.19.5347 ID - Adachi1999 ER - TY - JOUR AU - Burack, W. R. AU - Shaw, A. S. PY - 2005 DA - 2005// TI - Live cell imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M410031200 DO - 10.1074/jbc.M410031200 ID - Burack2005 ER - TY - JOUR AU - Khokhlatchev, A. V. AU - Canagarajah, B. AU - Wilsbacher, J. AU - Robinson, M. AU - Atkinson, M. AU - Goldsmith, E. AU - Cobb, M. H. PY - 1998 DA - 1998// TI - Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation JO - Cell VL - 93 UR - https://doi.org/10.1016/S0092-8674(00)81189-7 DO - 10.1016/S0092-8674(00)81189-7 ID - Khokhlatchev1998 ER - TY - JOUR AU - Wolf, I. AU - Rubinfeld, H. AU - Yoon, S. AU - Marmor, G. AU - Hanoch, T. AU - Seger, R. PY - 2001 DA - 2001// TI - Involvement of the activation loop of ERK in the detachment from cytosolic anchoring JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M103352200 DO - 10.1074/jbc.M103352200 ID - Wolf2001 ER - TY - JOUR AU - Horgan, A. M. AU - Stork, P. J. S. PY - 2003 DA - 2003// TI - Examining the mechanism of Erk nuclear translocation using green fluorescent protein JO - Exp Cell Res VL - 285 UR - https://doi.org/10.1016/S0014-4827(03)00037-5 DO - 10.1016/S0014-4827(03)00037-5 ID - Horgan2003 ER - TY - JOUR AU - Philipova, R. AU - Whitaker, M. PY - 2005 DA - 2005// TI - Active ERK1 is dimerized in vivo: bisphosphodimers generate peak kinase activity and monophosphodimers maintain basal ERK1 activity JO - J Cell Sci VL - 118 UR - https://doi.org/10.1242/jcs.02683 DO - 10.1242/jcs.02683 ID - Philipova2005 ER - TY - JOUR AU - Fukuda, M. AU - Gotoh, I. AU - Gotoh, Y. AU - Nishida, E. PY - 1996 DA - 1996// TI - Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2 terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal JO - J Biol Chem VL - 271 UR - https://doi.org/10.1074/jbc.271.33.20024 DO - 10.1074/jbc.271.33.20024 ID - Fukuda1996 ER - TY - JOUR AU - Shibayama, S. AU - Shibata-Seita, R. AU - Miura, K. AU - Kirino, Y. AU - Takishima, K. PY - 2002 DA - 2002// TI - Identification of a C-terminal region that is required for the nuclear translocation of ERK2 by passive diffusion JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M206163200 DO - 10.1074/jbc.M206163200 ID - Shibayama2002 ER - TY - JOUR AU - Waas, W. F. AU - Rainey, M. A. AU - Szafranska, A. E. AU - Dalby, K. N. PY - 2003 DA - 2003// TI - Two rate-limiting steps in the kinetic mechanism of the serine/threonine specific protein kinase ERK2: a case of fast phosphorylation followed by fast product release JO - Biochemistry VL - 42 UR - https://doi.org/10.1021/bi0348617 DO - 10.1021/bi0348617 ID - Waas2003 ER - TY - JOUR AU - Cobb, M. H. AU - Goldsmith, E. J. PY - 2000 DA - 2000// TI - Dimerization in MAP-kinase signaling JO - Trends Biochem Sci VL - 25 UR - https://doi.org/10.1016/S0968-0004(99)01508-X DO - 10.1016/S0968-0004(99)01508-X ID - Cobb2000 ER - TY - JOUR AU - Kumar, N. V. AU - Bernstein, L. R. PY - 2001 DA - 2001// TI - Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M103677200 DO - 10.1074/jbc.M103677200 ID - Kumar2001 ER - TY - JOUR AU - Zhang, H. AU - Shi, X. AU - Hampong, M. AU - Blanis, L. AU - Pelech, S. PY - 2001 DA - 2001// TI - Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.C000917200 DO - 10.1074/jbc.C000917200 ID - Zhang2001 ER - TY - JOUR AU - Efimova, T. AU - Broome, A. -. M. AU - Eckert, R. L. PY - 2003 DA - 2003// TI - A regulatory role for p38-delta MAPK in keratinocyte differentiation: evidence for p38-delta-ERK1/2 complex formation JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M302759200 DO - 10.1074/jbc.M302759200 ID - Efimova2003 ER - TY - JOUR AU - Aguirre-Ghiso, J. A. AU - Estrada, Y. AU - Liu, D. AU - Ossowski, L. PY - 2003 DA - 2003// TI - ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK) JO - Cancer Res VL - 63 ID - Aguirre-Ghiso2003 ER - TY - JOUR AU - Sanz-Moreno, V. AU - Casar, B. AU - Crespo, P. PY - 2003 DA - 2003// TI - p38α isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels JO - Mol Cell Biol VL - 23 UR - https://doi.org/10.1128/MCB.23.9.3079-3090.2003 DO - 10.1128/MCB.23.9.3079-3090.2003 ID - Sanz-Moreno2003 ER - TY - JOUR AU - McCaw, B. J. AU - Chow, S. Y. AU - Wong, E. S. AU - Tan, K. L. AU - Guo, H. AU - Guy, G. R. PY - 2005 DA - 2005// TI - Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant JO - Gene VL - 345 UR - https://doi.org/10.1016/j.gene.2004.11.011 DO - 10.1016/j.gene.2004.11.011 ID - McCaw2005 ER - TY - JOUR AU - Kallunki, T. AU - Deng, T. AU - Hibi, M. AU - Karin, M. PY - 1996 DA - 1996// TI - c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions JO - Cell VL - 87 UR - https://doi.org/10.1016/S0092-8674(00)81999-6 DO - 10.1016/S0092-8674(00)81999-6 ID - Kallunki1996 ER - TY - JOUR AU - Ohren, J. F. AU - Chen, H. AU - Pavlovsky, A. AU - Whitehead, C. AU - Zhang, E. AU - Kuffa, P. AU - Yan, C. AU - McConnell, P. AU - Spessard, C. AU - Banotai, C. PY - 2004 DA - 2004// TI - Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition JO - Nat Struct Mol Biol VL - 11 UR - https://doi.org/10.1038/nsmb859 DO - 10.1038/nsmb859 ID - Ohren2004 ER - TY - JOUR AU - Inouye, K. AU - Mizutani, S. AU - Koide, H. AU - Kaziro, Y. PY - 2000 DA - 2000// TI - Formation of the Ras dimer is essential for Raf-1 activation JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.275.6.3737 DO - 10.1074/jbc.275.6.3737 ID - Inouye2000 ER - TY - JOUR AU - Weber, C. K. AU - Slupsky, J. R. AU - Kalmes, H. A. AU - Rapp, U. R. PY - 2001 DA - 2001// TI - Active Ras induces heterodimerization of cRaf and BRaf JO - Cancer Res VL - 61 ID - Weber2001 ER - TY - JOUR AU - Garnett, M. J. AU - Rana, S. AU - Paterson, H. AU - Barford, D. AU - Marais, R. PY - 2005 DA - 2005// TI - Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization JO - Mol Cell VL - 20 UR - https://doi.org/10.1016/j.molcel.2005.10.022 DO - 10.1016/j.molcel.2005.10.022 ID - Garnett2005 ER - TY - JOUR AU - Rushworth, L. K. AU - Hindley, A. D. AU - O'Neill, E. AU - Kolch, W. PY - 2006 DA - 2006// TI - Regulation and role of Raf-1/B-Raf heterodimerization JO - Mol Cell Biol VL - 26 UR - https://doi.org/10.1128/MCB.26.6.2262-2272.2006 DO - 10.1128/MCB.26.6.2262-2272.2006 ID - Rushworth2006 ER - TY - JOUR AU - Xing, H. AU - Kornfeld, K. AU - Muslin, A. J. PY - 1997 DA - 1997// TI - The protein kinase KSR interacts with 14-3-3 protein and Raf JO - Curr Biol VL - 7 UR - https://doi.org/10.1016/S0960-9822(06)00152-7 DO - 10.1016/S0960-9822(06)00152-7 ID - Xing1997 ER - TY - JOUR AU - Glantschnig, H. AU - Rodan, G. A. AU - Reszka, A. A. PY - 2002 DA - 2002// TI - Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M208538200 DO - 10.1074/jbc.M208538200 ID - Glantschnig2002 ER - TY - JOUR AU - Praskova, M. AU - Khoklatchev, A. AU - Ortiz-Vega, S. AU - Avruch, J. PY - 2004 DA - 2004// TI - Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras JO - Biochem J VL - 381 UR - https://doi.org/10.1042/BJ20040025 DO - 10.1042/BJ20040025 ID - Praskova2004 ER - TY - JOUR AU - O'Neill, E. AU - Rushworth, L. AU - Baccarini, M. AU - Kolch, W. PY - 2004 DA - 2004// TI - Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1 JO - Science VL - 306 UR - https://doi.org/10.1126/science.1103233 DO - 10.1126/science.1103233 ID - O'Neill2004 ER - TY - JOUR AU - Hao, W. AU - Takano, T. AU - Guillemette, J. AU - Papillon, J. AU - Ren, G. AU - Cybulsky, A. V. PY - 2006 DA - 2006// TI - Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38 JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M511744200 DO - 10.1074/jbc.M511744200 ID - Hao2006 ER - TY - JOUR AU - Yustein, J. T. AU - Xia, L. AU - Kahlenburg, J. M. AU - Robinson, D. AU - Templeton, D. AU - Kung, H. J. PY - 2003 DA - 2003// TI - Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38 JO - Oncogene VL - 22 UR - https://doi.org/10.1038/sj.onc.1206605 DO - 10.1038/sj.onc.1206605 ID - Yustein2003 ER - TY - JOUR AU - Song, J. J. AU - Lee, Y. J. PY - 2003 DA - 2003// TI - Role of the ASK1-SEK1-JNK1-HIPK1 signaling Daxx trafficking and ASK1 oligomerization JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M213201200 DO - 10.1074/jbc.M213201200 ID - Song2003 ER - TY - JOUR AU - Cheng, J. AU - Yu, L. AU - Zhang, D. AU - Huang, Q. AU - Spencer, D. AU - Su, B. PY - 2005 DA - 2005// TI - Dimerization through the catalytic domain is essential for MEKK2 activation JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M414258200 DO - 10.1074/jbc.M414258200 ID - Cheng2005 ER - TY - JOUR AU - Abell, A. N. AU - Johnson, G. L. PY - 2005 DA - 2005// TI - MEKK4 is an effector of the embryonic TRAF4 for JNK activation JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.C500260200 DO - 10.1074/jbc.C500260200 ID - Abell2005 ER - TY - JOUR AU - Nihalani, D. AU - Merritt, S. AU - Holzman, L. B. PY - 2000 DA - 2000// TI - Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.275.10.7273 DO - 10.1074/jbc.275.10.7273 ID - Nihalani2000 ER - TY - JOUR AU - Hebert, S. S. AU - Daviau, A. AU - Grondin, G. AU - Latreille, M. AU - Aubin, R. A. AU - Blouin, R. PY - 2000 DA - 2000// TI - The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.M006528200 DO - 10.1074/jbc.M006528200 ID - Hebert2000 ER - TY - JOUR AU - Leung, I. W. AU - Lassam, N. PY - 2001 DA - 2001// TI - The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M004092200 DO - 10.1074/jbc.M004092200 ID - Leung2001 ER - TY - JOUR AU - Ikeda, A. AU - Masaki, M. AU - Kozutsumi, Y. AU - Oka, S. AU - Kawasaki, T. PY - 2001 DA - 2001// TI - Identification and characterization of functional domains in a mixed lineage kinase LZK JO - FEBS Lett VL - 488 UR - https://doi.org/10.1016/S0014-5793(00)02432-7 DO - 10.1016/S0014-5793(00)02432-7 ID - Ikeda2001 ER - TY - JOUR AU - Nahta, R. AU - Yuan, L. X. AU - Zhang, B. AU - Kobayashi, R. AU - Esteva, F. J. PY - 2005 DA - 2005// TI - Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-3841 DO - 10.1158/0008-5472.CAN-04-3841 ID - Nahta2005 ER - TY - JOUR AU - Saito, Y. AU - Haendeler, J. AU - Hojo, Y. AU - Yamamoto, K. AU - Berk, B. C. PY - 2001 DA - 2001// TI - Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation JO - Mol Cell Biol VL - 21 UR - https://doi.org/10.1128/MCB.21.19.6387-6394.2001 DO - 10.1128/MCB.21.19.6387-6394.2001 ID - Saito2001 ER -