TY - JOUR AU - Itoh, Yuichiro AU - Melamed, Esther AU - Yang, Xia AU - Kampf, Kathy AU - Wang, Susanna AU - Yehya, Nadir AU - Van Nas, Atila AU - Replogle, Kirstin AU - Band, Mark R. AU - Clayton, David F. AU - Schadt, Eric E. AU - Lusis, Aldons J. AU - Arnold, Arthur P. PY - 2007 DA - 2007/03/22 TI - Dosage compensation is less effective in birds than in mammals JO - Journal of Biology SP - 2 VL - 6 IS - 1 AB - In animals with heteromorphic sex chromosomes, dosage compensation of sex-chromosome genes is thought to be critical for species survival. Diverse molecular mechanisms have evolved to effectively balance the expressed dose of X-linked genes between XX and XY animals, and to balance expression of X and autosomal genes. Dosage compensation is not understood in birds, in which females (ZW) and males (ZZ) differ in the number of Z chromosomes. SN - 1475-4924 UR - https://doi.org/10.1186/jbiol53 DO - 10.1186/jbiol53 ID - Itoh2007 ER -