Table 1 Groups of relevant biological processes regulated at the protein-expression level
From: Growth control of the eukaryote cell: a systems biology study in yeast
Upregulated | Â | Â |
|---|---|---|
Biological process | Proteins (examples) | p-value (GO studies) |
Cellular biosynthesis (81) | Ser3p, Cpa1p, Lia1p Rpl10p | 1.1E-29 |
Amino-acid and derivative metabolism (33) | Gln1p, Leu1p, Lys4p | 2.6E-21 |
Translation (42) | Rpl6ap, Mes1p, Sui3p, Fun12p | 4.8E-13 |
Macromolecule biosynthesis (48) | Mdh2p, Rpl3p, Mes1p, Ths1p | 5.7E-12 |
tRNA aminoacylation (9) | Mes1p, Cdc60p, Ded81p | 9.7E-9 |
Ribosome biogenesis and assembly (22) | Nug1p, Rpl30p, Nop58p, Yf3p | 3.2E-7 |
Purine nucleotide metabolism (8) | Ade17p, Ade1p, Hpt1p | 3.8E-6 |
Sulfur metabolism (8) | Ecm17p, Met10p, Trx2p, Sam2p | 2.2E-5 |
Organic-acid biosynthesis (4) | Ald6p, Fas1p, Fas2p | 3.6E-4 |
Regulation of protein metabolism (6) | Asc1p, Cap2p, Rpl30p | 1.2E-3 |
rRNA processing (8) | Nug1p, Has1p, Utp10p | 1.8E-2 |
Downregulated | Â | Â |
Cellular carbohydrate metabolism (19) | Gre2p, Tsl1p, Tps1p, Eno1p | 2E-7 |
Coenzyme metabolism (14) | Pan5p, Mdh3p, Npt1p | 5.8E-7 |
Response to stress (27) | Pol30p, Hsp104p, Rvs161p | 9.8E-7 |
Response to stimulus (31) | Lap3p, Akr1p, Ycf1p, Fet3p | 1.1E-5 |
Cellular macromolecule catabolism (17) | Skp1p, Pre3p, Rpn3p, Kar2p | 2.3E-4 |
Vacuole organization and biogenesis (6) | Sec17p, Tpm1p, Vtc2p, Vtc3p | 3.6E-4 |
Transport (35) | Pet9p, Sar1p, Fet3p, Hxt3p | 1.1E-3 |
Cellular lipid metabolism (11) | Ncp1p, Erg1p, Erg27p. Lem3p | 7.7E-3 |
Homeostasis (7) | Skp1p, Ahp1p, Vma5p, Zrt3p | 2E-2 |