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Table 2 Amino-acid biosynthetic enzymes with protein levels consistently up- and downregulated with growth rate under all nutrient-limiting conditions

From: Growth control of the eukaryote cell: a systems biology study in yeast

 

Enzymes

Amino-acid biosynthetic pathway

Upregulated

Downregulated

Arginine

Aco1p, Aco2p, Cpa1p, Cpa2p

Arg1p, Arg8p

Homocysteine, cysteine, methionine, and sulfur compounds

Ecm17p, Met10p, Met13p, Sam2p, Met6p, Ado1p

Sam1p

Glutamine

Gln1p

 

Leucine, isoleucine, valine

Ilv3p, Leu1p

 

Lysine

Aco1p, Aco2p, Lys2p, Lys4p

 
  1. Aco1p, aconitase; Aco2p, putative aconitase isozyme; Ado1p; adenosine kinase; Arg1p, arginosuccinate synthetase; Arg8p, acetylornithine aminotransferase; Cpa1p, small subunit of carbamoyl phosphate synthetase; Cpa2p, large subunit of carbamoyl phosphate synthetase; Ecm17p, sulfite reductase beta subunit; Gln1p, glutamine synthetase; Ilv3p, dihydroxyacid dehydratase; Leu1p, isopropylmalate isomerase; Lys2p, alpha aminoadipate reductase; Lys4p, homoaconitase; Met6p, methionine synthase; Met10p, sulfite reductase alpha subunit; Met13p, methylenetetrahydrofolate reductase isozyme; Sam1p, S-adenosylmethionine synthetase isozyme; Sam2p, S-adenosylmethionine synthetase isozyme.
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Journal of Biology

ISSN: 1475-4924