Skip to main content


Table 1 A summary of the query genes

From: A global analysis of genetic interactions in Caenorhabditis elegans

Query gene Ortholog (pathway) Null/strong loss-of-function phenotype(s) Hypomorphic phenotype(s) References
let-756 FGF (FGF) Early larval arrest (s2887) scrawny, Slo (s2613)** [77]
egl-15 FGF receptor (FGF) Early larval arrest (n1456) scrawny, Egl (n1477)** [78]
let-23 EGF receptor (EGF) L1 arrest (mn23) ts Vul, pleotropic (n1045)** [79]
daf-2 Insulin growth factor receptor (insulin) Emb (e979) ts Daf-c (e1370)** [35]
sem-5 GRB-2 (EGF, FGF, insulin) L1 arrest (leaky) (n1619) Egl, Vul (n2019)* [79,80]
sos-1 Guanine-nucleotide exchange factor (EGF, FGF) Emb (s1031) ts Egl, Vul (cs41)* [33]
let-60 RAS (EGF, FGF, insulin, Wingless/Wnt) Mid-larval lethal (leaky) (s1124) Egl, Vul (n2021)* [81,82]
glp-1 Notch receptor (Notch) ts Emb (gp60) ts Emb, Glp, Muv (or178)* [47]
bar-1 β-catenin (Wingless (Wnt)) Mig, Vul, Pvl (ga80)** Mig, Vul, Pvl (mu63) [34]
sma-6 Type I TGF-β receptor (TGF-β) Sma, Mab (wk7) Sma (e1482)* [83]
clk-2 Tel-2p (DNA-damage response) Unknown Slo, Ste, ts Emb (mn159)** [84]
  1. In the second column, 'ortholog' refers to the canonical ortholog in yeast, flies, mice, or humans. The pathway to which the ortholog belongs is in brackets. Third column: if known, the null or strong loss-of-function phenotype is shown. Fourth column: weak loss-of-function (hypomorphic) phenotypes are shown for representative alleles. Phenotypic acronyms: Emb, embryonic lethal; Daf-c, dauer formation constitutive; Slo, slow growth; Egl, egg-laying defective; Vul, vulvaless; Glp, germ-line proliferation defects; Muv, multivulva; Mig, cell and/or axon migration defects; Pvl, protruding vulva; Sma, small body; Mab, male tail abnormal; Ste, sterile; ts, temperature sensitive. The alleles used in this study are followed by two asterisks if used as a query against both the signaling targets and the LGIII targets, or just a single asterisk if used only against the signaling targets.