Table 1 Summary of GDAsBMP, GDAsCNTF and GRPs effects on spinal cord injury repair and allodynia
Effect | GDAsBMP | GDAsCNTF | GRPs |
|---|---|---|---|
Promote axon growth across spinal cord injury | +++ | - | - |
Promote locomotor recovery | +++ | - | - |
Suppress atrophy of injured red nucleus neurons | +++ | - | - |
Induce mechanical and thermal allodynia | - | +++ | +++ |
Promote sprouting of CGRP+ axons in lamina III | - | +++ | +++ |
Align host astrocytes at injury site | +++ | - | - |
Transiently suppress host CSPG expression | +++ | +++ | +++ |
Express inhibitory CSPGs within injury site | - | +++ | +++ |
Express CSPGs in vitro | + | +++ | +++ |