Mechanisms of ubiquitin transfer by the anaphase-promoting complex

Journal of Biology

Table 1 APC subunits in different organisms

S. cerevisiae	S. pombe	Mammals	D. melanogaster	Comments
Core subunits
Apc1	Cut4	Apc1/Tsg24
Apc2	Apc2	Apc2		Cullin domain
Cdc27	Nuc2	Cdc27		TPRs
Apc4	Lid1	Apc4
Apc5	Apc5	Apc5
Cdc16	Cut9	Apc6		TPRs
-	-	Apc7		TPRs
Cdc23	Cut23	Cdc23		TPRs
Apc9	-	-
Doc1	Apc10	Apc10		Doc domain
Apc11	Apc11	Apc11		RING finger
Cdc26	Hcn1	Cdc26
Swm1	Apc13	-
Mnd2	Apc15	-
-	Apc14	-
Activators
Cdc20	Slp1	Cdc20/p55^CDC	Fizzy/FZY	WD40 repeats
Cdh1/Hct1	Srw1/Ste9	Cdh1	Fizzy-related/FZR	WD40 repeats
Ama1	Mfr1			Meiosis-specific

Dashes indicate that no homologous subunit has been identified in that species. Most core subunits are not yet identified in Drosophila melanogaster. Motifs in APC subunits include tetratricopeptide repeats (TPRs) and WD40 repeats, both of which form domains that are typically involved in protein-protein interactions. Modified from [6].